Team 2: Osteoimmunology, niches and inflammation

Team leader: Claudine Blin Bone marrow is the site of bone remodeling and immune cell differentiation, as well as a major site for the maintenance of memory lymphocytes. Interactions between bone cells (osteoclasts, osteoblasts), immune cells and their progenitors are therefore permanent and fundamental. Dysregulation of these interactions is associated with many pathologies, including chronic inflammatory diseases frequently characterized by severe bone destruction. The projects we are developing are intended to dissect these interactions and to determine how they contribute to the maintenance of bone and immuno-hematological system homeostasis. They are conducted either in a physiological context, or in a context of chronic inflammation associated with bone defects (Crohn's disease, rheumatoid arthritis, osteoporosis, transplant rejection).

Key words

Osteoclast, osteoimmunology, lymphocyte, mesenchymal stromal cells, hematopoietic niches, chronic inflammation, immune memory, pluripotent stem cells

Team members

BLIN Claudine, DR2 INSERM, Team leader
ROULEAU Matthieu, CR1 INSERM
VOHA Christine, MCU-PH, CHU odontology
WAKKACH Abdelilah, DR2 CNRS
TOPI Majlinda, TR CNRS
AOUAD Amaury, master UNS
BOUTIN Antoine, AI CNRS CDD
HALPER Julia, PhD UCA
MADEL Maria-Bernadette, Postdoc UCA
SILVA Diana, post-doc CNRS

Fundings

Equipe FRM ANR Arthitis SFR SFD

IFRO groupe pasteur mutualité Logo AFA OSCAR logo region PACA

logo biocodex logo AFM Logo SFBTM

 

Belonging to learned societies

Société Française d'Immunologie

Société Française de Biologie des Tissus Minéralisés

European Calcified Tissue Society

Société Française de Rhumatologie