Mathieu GRUET


chercheur (Maître de conférences)
Laboratoire Motricité Humaine, Expertise, Sport, Santé (LAMHESS)



My research focuses on the neuromuscular function of special populations, from trained athletes (e.g. runners) to people with chronic diseases (e.g. COPD, CF, OSA). I am notably interested in the impact of peripheral and central factors on the fatigue observed in demanding contexts, including prolonged cognitive-motor dual tasks and downhill running. 

Recent Publications (2016-2019)

  • R. Radel, M. Gruet, K. Barzykowski (2019) Testing the ego-depletion effect in optimized conditions. PLoS One. 2019 Mar 7;14(3):e0213026. doi: 10.1371/journal.pone.0213026. 
  • C. Chatain, R. Radel, F. Vercruyssen, T. Rabahi, T. Bernard, M. Gruet (2019) The influence of cognitive load on the dynamics of neurophysiological adjustments during fatiguing exercises. Psychophysiology. 2019 Feb 7:e13343. doi: 10.1111/psyp.13343.
  • M. Gruet, Z. Saynor (2019) Assessment of peripheral muscle function in cystic fibrosis: why and how? Respir Care. 2019 Feb;64:2. doi: 10.4187/respcare.06692.
  • S. Ehrstrom, M. Gruet, M. Giandolini, S. Chapuis, JB. Morin, F. Vercruyssen (2018) Acute and delayed neuromuscular alterations induced by downhill running in trained trail runners: beneficial effects of high-pressure compression garments. Front Physiol. 2018 Nov 28;9:1627. doi: 10.3389/fphys.2018.01627. 
  • M. Gruet (2018) Fatigue in chronic respiratory diseases: theoretical framework and implications for real-life performance and rehabilitation. Front Physiol. 2018 Sep 19;9:1285. doi: 10.3389/fphys.2018.01285. 
  • G. Roussey, M. Gruet, F. Vercruyssen, JM. Vallier, J. Louis, T. Bernard (2018) Interactions between perceived exertion and thermal perception in the heat in endurance athletes. J Therm Biol. 2018 Aug;76:68-76. doi: 10.1016/j.jtherbio.2018.07.006. 
  • M. Marillier, M. Gruet, S. Baillieul, B. Wuyam, R. Tamisier, P Lévy, JL. Pépin, S. Verges (2018) Impaired cerebral oxygenation and exercise tolerance in patients with severe obstructive sleep apnea syndrome. Sleep Med. 2018 Nov;51:37-46. doi: 10.1016/j.sleep.2018.06.013.
  • M. Gruet, L. Mely, JM. Vallier (2018) Overall and differentiated sensory responses to cardiopulmonary exercise test in patients with cystic fibrosis: kinetics and ability to predict peak oxygen uptake. Eur J Appl Physiol. 2018 Jul 9. doi: 10.1007/s00421-018-3923-y. 
  • M. Marillier, M. Gruet, S. Baillieul, T. Le Roux Mallouf, B. Wuyam, R. Tamisier, P Lévy, JL. Pépin, S. Verges (2018) Neuromuscular dysfunction and cortical impairments during exercise in patients with severe obstructive sleep apnea syndrome. Med Sci Sports Exerc. 2018 Apr 27. doi: 10.1249/MSS.0000000000001625.
  • Delextrat, M. Gruet, F. Bieuzen (2018) Effects of small-sided games and high-intensity interval training on aerobic and repeated sprint performance and peripheral muscle oxygenation changes in elite junior basketball players. Journal of Strength and Conditioning Research. 2018 Mar 6. doi: 10.1519/JSC.0000000000002570.
  • MA. Sanseverino, M. Pecchiari, RL. Bona, DC Berton, FB de Queiroz, M. Gruet, L. Peyré-Tartaruga (2018) Limiting Factors in Walking Performance of Patients with COPD. Respir Care. 2018 Mar;63(3):301-310. doi: 10.4187/respcare.05768.
  • M. Gruet, J. Larribaut, T. Troosters, S. Vergès (2017) Larger studies controlling for CFTR class mutations are necessary to infer on the potential presence of an intrinsic skeletal muscle function deficit in patients with cystic fibrosis. J Physiol 000.00 (2017) pp 1–5.
  • M. Gruet, Z. Saynor (2017) Multimodal exercise evaluation is needed to truly determine the functional consequences of altered skeletal muscle oxidative capacity in cystic fibrosis. J Physiol 000.00 (2017) pp 1–5.
  • M. Gruet, T. Troosters, S. Vergès (2017) Peripheral muscle abnormalities in cystic fibrosis: aetiology, clinical implications and response to therapeutic interventions. J Cyst Fibros. 2017 Sep;16(5):538-552. doi: 10.1016/j.jcf.2017.02.007.
  • N. Decorte, M. Gruet*, Camara, S. Quetant, L. Mely, JM. Vallier, S. Verges, B. Wuyam (2017) Absence of calf muscle metabolism alterations in active cystic fibrosis adults with mild to moderate lung disease. J Cyst Fibros. 2017 Jan;16(1):98-106. doi: 10.1016/j.jcf.2016.05.010. (* share first authorship)
  • F. Vercruyssen, M. Gruet, S. Colson, S. Ehrstrom, J. Brisswalter (2017) Compression garments, muscle contractile function and economy in trail runners. Int J Sports Physiol Perform. 2017 Jan;12(1):62-68. doi: 10.1123/ijspp.2016-0035.
  • M. Gruet, N. Decorte, L. Mely, JM. Vallier, B. Camara, S. Quetant, B. Wuyam, S. Verges (2016) Skeletal muscle contractility and fatigability in adults with cystic fibrosis. J Cyst Fibros. 2016 Jan;15(1):e1-8. doi: 10.1016/j.jcf.2015.05.004.
  • M. Gruet, L. Peyré-Tartaruga, L. Mely, JM. Vallier (2016) The 1-min sit-to-stand test in adults with cystic fibrosis: relations with cardiopulmonary exercise test, six minute walk test and quadriceps strength. Respir Care. 2016 Dec;61(12):1620-1628.
  • D. Bachasson, J. Temesi, M. Gruet, K. Yokoyama, T. Rupp, GY. Millet, S. Verges (2016) Transcranial Magnetic Stimulation Intensity affects Exercise-Induced changes in Corticomotoneuronal Excitability and Inhibition and Voluntary Activation. Neuroscience. 2016 Feb 9;314:125-33. doi: 10.1016/j.neuroscience.2015.11.056.
  • R. Radel, D. Pjevac , K. Davranche , F. d’Arripe-Longueville , SS Colson , T. Lapole , M. Gruet (2016) Does intrinsic motivation enhance motor cortex excitability? Psychophysiology. 2016 Nov;53(11):1732-1738. doi: 10.1111/psyp.12732.
  • JM. Vallier, M. Rouissi, L. Mely, M. Gruet (2016) Physiological responses of the modified shuttle test in adults with cystic fibrosis. J Cardiopulm Rehabil Prev. 2016 Jul-Aug;36(4):288-92. doi: 10.1097/HCR.0000000000000181.


Recherche et activités
Domaines de recherche
Physiologie musculaire
Projets de recherche

Projets principaux

2018-2020: NEUROTIGUE

Responsabilité scientifique du programme de recherche NEUROTIGUE financé par contrat doctoral UTLN qui vise à une meilleure compréhension de la fatigue dans la BPCO. Directeur de thèse JM Vallier, étudiant en thèse C Chatain.

2016-2019 : MUCOBEX 

Collaborateur d'un programme de recherche financé par l’Association Grégory Lemarchal (responsable scientifique F D'Arripe-Longueville). "Les barrières psychologiques à l'exercice physique chez les patients atteints de mucoviscidose: développement d'un outil de mesure et relations avec la tolérance à l'effort et la qualité de vie – MUCO-BEX ». Programme de recherche multicentrique impliquant les CHU de Nice, Giens et Grenoble.

2016-2019: MUCOMUREE

Co-responsabilité scientifique centre Toulonnais d'un programme de recherche visant à mieux comprendre la fonction des muscles respiratoires chez l'adulte atteint de mucoviscidose. Responsable scientifique Samuel Vergès, Université de Grenoble, laboratoire HP2. Financements Grenoble (bourse doctoral, Agir à Dom) et localement AAP UTLN 2016-2018.

2016-2020: Human locomotion and cardiorespiratory disoders

Collaborateur d'un projet international visant à une meilleure compréhension des mécanismes sous-jacent à l'intolérance à l'effort dans les maladies chroniques respiratoires (BPCO, pathologies interstitielles...). Responsable scientifique L.Peyré-Tartaruga (Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil)